Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 9/20 | 0.63 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.59 |
| ▸ | DHCR7 | Q9UBM7 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789784 | 0.95 | ABCB1 (0.63) | ABCB1ABCG2DHCR7SIGMAR1 | |
| SCHEMBL3157251 | 0.87 | ABCB1 (0.62) | ABCB1ABCG2SIGMAR1ADRA1DADRA1A | |
| SCHEMBL2771882 | 0.85 | ABCB1 (0.78) | ABCB1ABCG2DHCR7 | |
| Hydrochloric Acid SCHEMBL10661663 | 0.84 | ABCB1 (0.76) | ABCB1ABCG2DHCR7 | |
| SCHEMBL8789944 | 0.82 | KCNJ1 (0.67) | ABCB1ABCG2HRH3 | |
| SCHEMBL7743687 | 0.82 | ABCB1 (0.62) | ABCB1DHCR7SIGMAR1ADRA1DADRA1A | |
| SCHEMBL3156807 | 0.82 | ABCB1 (0.62) | ABCB1ABCG2SIGMAR1ADRA1DADRA1A | |
| SCHEMBL3148037 | 0.82 | HDAC1 (0.65) | ABCB1ABCG2SIGMAR1ADRA1DADRA1A | |
| SCHEMBL17664977 | 0.80 | DHCR7 (0.79) | ABCB1ABCG2DHCR7 | |
| SCHEMBL14330769 | 0.80 | DHCR7 (0.79) | ABCB1ABCG2DHCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0569380-A1 | ACRIDINE DERIVATIVES. | GLAXO LAB SA (FR) | 1993-11-18 | — | — | EP | disclosed |
| WO-1992012132-A1 | ACRIDINE DERIVATIVES | LABORATOIRES GLAXO S.A. (FR) | 1992-07-23 | — | — | WO | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |