SCHEMBL14330769

SCHEMBL14330769

COc1cc2c(cc1O)CN(CCc1ccc(N)cc1)CC2

nearest known ligand 0.79

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DHCR7 Q9UBM7 3/20 0.79
ABCB1 P08183 13/20 0.70
ABCG2 Q9UNQ0 7/20 0.70
KDM4E B2RXH2 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
CA2 P00918 1/20 0.58
CA9 Q16790 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17664977 1.00 DHCR7 (0.79) DHCR7ABCB1ABCG2KDM4ETDP1
SCHEMBL2771882 0.92 ABCB1 (0.78) DHCR7ABCB1ABCG2
Hydrochloric Acid SCHEMBL10661663 0.90 ABCB1 (0.76) DHCR7ABCB1ABCG2
SCHEMBL3042454 0.89 DHCR7 (0.81) DHCR7ABCB1ABCG2KDM4ETDP1
SCHEMBL14740411 0.88 DHCR7 (0.79) DHCR7ABCB1ABCG2KDM4ETDP1
SCHEMBL14739580 0.88 DHCR7 (1.00) DHCR7ABCB1ABCG2KDM4ETDP1
SCHEMBL3504140 0.88 DHCR7 (0.79) DHCR7ABCB1ABCG2KDM4ETDP1
SCHEMBL14740106 0.87 DHCR7 (1.00) DHCR7ABCB1ABCG2KDM4ETDP1
Verilopam SCHEMBL489188 0.85 ABCB1 (0.68) DHCR7ABCB1ABCG2
SCHEMBL8790535 0.84 ABCB1 (0.68) DHCR7ABCB1ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3200779-B1 NOVEL ANTHRANILIC ACID DERIVATIVES MAHESHWARI DIVYA (IN) 2022-03-23 EP disclosed
US-10561748-B2 Anthranilic acid derivatives MAHESHWARI DIVYA (IN) 2020-02-18 US disclosed
US-20170281805-A1 NOVEL ANTHRANILIC ACID DERIVATIVES MAHESHWARI DIVYA (IN) 2017-10-05 US disclosed
EP-3200779-A2 NOVEL ANTHRANILIC ACID DERIVATIVES Maheshwari, Divya (IN) 2017-08-09 EP disclosed
WO-2016051306-A2 NOVEL ANTHRANILIC ACID DERIVATIVES MAHESHWARI DIVYA (IN) 2016-04-07 WO disclosed
US-20120330020-A1 METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME HANMI SCIENCE CO., LTD (KR) 2012-12-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170281805-A1 NOVEL ANTHRANILIC ACID DERIVATIVES SLC47A1, ABCC1, ABCB1 DHCR7 1395/4885ABCB1 3/4885ABCG2 12/4885
US-10561748-B2 Anthranilic acid derivatives SLC47A1, ABCC1, ABCB1 DHCR7 1590/4885ABCB1 3/4885ABCG2 14/4885
US-20120330020-A1 METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME TST, MPST, STS DHCR7 221/4885ABCB1 3899/4885ABCG2 1697/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.