Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 14/20 | 0.69 |
| ▸ | MAOB | P27338 | 2/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | ABCC1 | P33527 | 7/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790998 | 0.91 | ABCB1 (0.71) | ABCB1MAOBMAOAABCC1 | |
| SCHEMBL8789885 | 0.86 | ABCB1 (0.78) | ABCB1MAOBMAOAABCC1 | |
| SCHEMBL8790224 | 0.82 | ABCB1 (0.62) | ABCB1MAOBMAOAABCC1 | |
| SCHEMBL7256134 | 0.81 | ABCB1 (0.78) | ABCB1MAOBMAOAABCC1 | |
| SCHEMBL8789425 | 0.81 | DHCR7 (0.65) | ABCB1 | |
| SCHEMBL8790607 | 0.80 | ABCB1 (0.78) | ABCB1MAOBMAOAABCC1 | |
| SCHEMBL8790618 | 0.79 | ABCB1 (0.71) | ABCB1MAOBMAOAABCC1 | |
| SCHEMBL12005974 | 0.78 | HRH3 (0.62) | — | |
| SCHEMBL8789776 | 0.78 | ABCB1 (0.65) | ABCB1MAOBMAOAABCC1 | |
| SCHEMBL14419243 | 0.77 | KDM4E (0.59) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |