Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 11/20 | 0.78 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789885 | 0.94 | ABCB1 (0.78) | ABCB1ABCC1ABCG2MAOBMAOA | |
| SCHEMBL2771882 | 0.82 | ABCB1 (0.78) | ABCB1ABCG2KMT2A | |
| SCHEMBL8790998 | 0.82 | ABCB1 (0.71) | ABCB1ABCC1MAOBMAOA | |
| SCHEMBL4417186 | 0.81 | ABCB1 (0.55) | ABCB1ABCG2ALDH1A1LMNAMAPT | |
| SCHEMBL7256134 | 0.81 | ABCB1 (0.78) | ABCB1ABCC1MAOBMAOAREV1 | |
| Hydrochloric Acid SCHEMBL10661663 | 0.81 | ABCB1 (0.76) | ABCB1ABCG2KMT2A | |
| SCHEMBL8808208 | 0.80 | PRMT5 (0.60) | ABCB1KMT2A | |
| SCHEMBL8789908 | 0.80 | ABCB1 (0.69) | ABCB1ABCC1MAOBMAOA | |
| SCHEMBL8790535 | 0.80 | ABCB1 (0.68) | ABCB1ABCG2KMT2A | |
| SCHEMBL8790123 | 0.80 | ABCB1 (0.58) | ABCB1ABCG2MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |