Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.57 |
| ▸ | GALR3 | O60755 | 2/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789971 | 0.90 | PPARG (0.65) | PPARGRAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL9094539 | 0.88 | PPARG (0.77) | PPARGKDM4EALDH1A1HSD17B10ABCC3 | |
| SCHEMBL9095451 | 0.86 | PPARG (0.69) | PPARGKDM4EALDH1A1HSD17B10ABCC3 | |
| SCHEMBL9094852 | 0.82 | PPARG (0.79) | PPARGKDM4EALDH1A1HSD17B10ABCC3 | |
| SCHEMBL6170465 | 0.80 | PPARG (0.52) | PPARGAGTR1SPHK1 | |
| SCHEMBL29390517 | 0.80 | PPARG (0.73) | PPARGKDM4EALDH1A1HSD17B10ABCC3 | |
| SCHEMBL2020774 | 0.80 | PPARG (0.73) | PPARGKDM4EALDH1A1HSD17B10ABCC3 | |
| SCHEMBL7303983 | 0.80 | PPARG (0.53) | PPARGKDM4EALDH1A1HSD17B10ABCC3 | |
| SCHEMBL8791687 | 0.79 | GALR3 (0.43) | PPARGGALR3NR2F2RAB9ATNF | |
| SCHEMBL7304123 | 0.79 | PPARG (0.68) | PPARGKDM4EALDH1A1HSD17B10ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468470-B1 | Benzimidazoles, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-04-16 | — | — | EP | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |
| EP-0468470-A1 | Benzimidazoles, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-01-29 | — | — | EP | disclosed |