SCHEMBL2020774

SCHEMBL2020774

CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C#N)cc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 5/20 0.73
KDM4E B2RXH2 1/20 0.73
ABCC3 O15438 1/20 0.73
ABCC4 O15439 1/20 0.73
USP2 O75604 1/20 0.73
ABCB11 O95342 1/20 0.73
ALDH1A1 P00352 1/20 0.73
CHRM2 P08172 1/20 0.73
CYP3A4 P08684 1/20 0.73
ADRA2A P08913 1/20 0.73
ADORA3 P0DMS8 1/20 0.73
CHRM1 P11229 1/20 0.73
CYP2C9 P11712 1/20 0.73
ACE P12821 1/20 0.73
ADRA2C P18825 1/20 0.73
TBXA2R P21731 1/20 0.73
GLRA1 P23415 1/20 0.73
PDE4A P27815 1/20 0.73
HTR2A P28223 1/20 0.73
MAPK1 P28482 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29390517 1.00 PPARG (0.73) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL7309057 0.95 PPARG (0.66) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL7304123 0.93 PPARG (0.68) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL3679091 0.93 PPARG (0.65) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL7309650 0.92 PPARG (0.67) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL12463072 0.92 PPARG (0.72) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL2040839 0.91 PPARG (0.67) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL9094539 0.90 PPARG (0.77) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL8268211 0.90 PPARG (0.80) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL12664495 0.88 PPARG (0.77) PPARGKDM4EABCC3ABCC4USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060264491-A1 Telmisartan production process CHEMAGIS LTD. (IL) 2006-11-23 US claimed
CN-110836943-B Analysis method for impurity detection of telmisartan tablets and telmisartan capsules 江西杏林白马药业股份有限公司 2022-02-15 CN disclosed
CN-107966519-B High performance liquid chromatography analysis method and detection method of impurities in telmisartan 威特(湖南)药业有限公司 2020-05-26 CN disclosed
CN-110836943-A Analysis method for impurity detection of telmisartan tablets and telmisartan capsules 江西杏林白马药业有限公司 2020-02-25 CN disclosed
US-9499491-B2 One pot process for the preparation of telmisartan AMARNATH U (IN) 2016-11-22 US disclosed
US-9499491-B2 One pot process for the preparation of telmisartan AMARNATH U (IN) 2016-11-22 US disclosed
US-20150197495-A1 ONE POT PROCESS FOR THE PREPARATION OF TELMISARTAN AMARNATH U (IN) 2015-07-16 US disclosed
US-20150197495-A1 ONE POT PROCESS FOR THE PREPARATION OF TELMISARTAN AMARNATH U (IN) 2015-07-16 US disclosed
US-8993778-B2 Process for manufacture of telmisartan BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-03-31 US disclosed
US-8993778-B2 Process for manufacture of telmisartan BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-03-31 US disclosed
US-20060264491-A1 Telmisartan production process CHEMAGIS LTD. (IL) 2006-11-23 US disclosed
WO-2004087676-A1 METHOD FOR THE PRODUCTION OF TELMISARTAN BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2004-10-14 WO disclosed
EP-0502314-B1 Benzimidazol derivatives, medicaments containing them and process for their preparation THOMAE GMBH DR K (DE) 1998-05-20 EP disclosed
US-5614519-A (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists KARL THOMAE GMBH (DE) 1997-03-25 US disclosed
US-5602127-A ADMINISTERING TO TREAT HYPERTENSION KARL THOMAE GMBH (DE) 1997-02-11 US disclosed
US-5594003-A HYPOTENSIVE AGENTS DR. KARL THOMAE GMBH (DE) 1997-01-14 US disclosed
US-5591762-A HYPOTENSIVE AGENTS DR. KARL THOMAE GMBH (DE) 1997-01-07 US disclosed
US-5565469-A HYPOTENSIVE AGENTS DR. KARL THOMAE GMBH (DE) 1996-10-15 US disclosed
EP-0682021-A1 Benzimidazoles, medicines containing them and process for their preparation Dr. Karl Thomae GmbH (DE) 1995-11-15 EP disclosed
EP-0502314-A1 Benzimidazol, medicaments containing them and process for their preparation Dr. Karl Thomae GmbH (DE) 1992-09-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060264491-A1 Telmisartan production process AGT, REN, ACE PPARG 2049/4885KDM4E 2878/4885ABCC3 4708/4885
US-20150197495-A1 ONE POT PROCESS FOR THE PREPARATION OF TELMISARTAN REN, AGTR1, AGT PPARG 3482/4885KDM4E 388/4885ABCC3 3388/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.