Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.63 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 4/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | DDO | Q99489 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568778 | 0.82 | PBRM1 (0.65) | PBRM1PARP1ALBFEN1DHODH | |
| SCHEMBL10526864 | 0.80 | PBRM1 (0.67) | PBRM1PARP1NQO1MPLKDM4E | |
| SCHEMBL8790155 | 0.80 | KDM4E (0.60) | PBRM1PARP1DHODHDYRK1AKDM4E | |
| SCHEMBL24743540 | 0.77 | PBRM1 (1.00) | PBRM1PARP1FEN1CDK5DYRK1A | |
| SCHEMBL7570648 | 0.77 | PBRM1 (0.71) | PBRM1PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL2445963 | 0.77 | PBRM1 (0.71) | PBRM1PARP1NQO1GSK3BDYRK1A | |
| SCHEMBL27416310 | 0.76 | KDM4E (0.57) | PBRM1PARP1FEN1DHODHKDM4E | |
| SCHEMBL5458223 | 0.75 | POLB (0.64) | PBRM1FEN1AURKAALOX5GSK3A | |
| SCHEMBL8519668 | 0.74 | PBRM1 (0.62) | PBRM1PARP1NQO1CDK5CDK5R1 | |
| SCHEMBL4943278 | 0.74 | PBRM1 (1.00) | PBRM1PARP1DYRK1AMPLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0569380-A1 | ACRIDINE DERIVATIVES. | GLAXO LAB SA (FR) | 1993-11-18 | — | — | EP | disclosed |
| WO-1992012132-A1 | ACRIDINE DERIVATIVES | LABORATOIRES GLAXO S.A. (FR) | 1992-07-23 | — | — | WO | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |