Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790649 | 0.89 | ALDH1A1 (0.52) | KCNH2KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL8790726 | 0.88 | ALDH1A1 (0.63) | KCNH2KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL8790512 | 0.87 | KCNH2 (0.57) | KCNH2KMT2ASMN1; SMN2MAPTCDK8 | |
| SCHEMBL8790387 | 0.86 | CDK8 (0.67) | KCNH2KMT2ASMN1; SMN2MAPTCDK8 | |
| SCHEMBL8789786 | 0.84 | CDK8 (0.56) | KMT2AMAPTCDK8CLK4MEN1 | |
| SCHEMBL8789844 | 0.84 | CDK8 (0.58) | KCNH2KMT2ASMN1; SMN2MAPTCDK8 | |
| SCHEMBL6573083 | 0.81 | KCNH2 (0.76) | KCNH2KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL8789624 | 0.81 | KCNH2 (0.71) | KCNH2SMN1; SMN2MAPTBCHEACHE | |
| SCHEMBL9053130 | 0.80 | KCNH2 (0.67) | KCNH2KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL8789459 | 0.78 | MAPK1 (0.68) | KCNH2KMT2ASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |