Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1259526 | 0.87 | SLC6A2 (0.36) | BRD4SLC6A2SLC6A4SLC6A3ADRB2 | |
| SCHEMBL3995068 | 0.85 | EPHX1 (0.37) | BRD4SLC6A2SLC6A4SLC6A3ADRB2 | |
| SCHEMBL5505238 | 0.85 | EPHX1 (0.37) | BRD4SLC6A2SLC6A4SLC6A3ADRB2 | |
| SCHEMBL26104068 | 0.85 | EPHX1 (0.37) | BRD4SLC6A2SLC6A4SLC6A3ADRB2 | |
| SCHEMBL18531916 | 0.85 | SLC6A2 (0.37) | BRD4SLC6A2SLC6A4SLC6A3ADRB2 | |
| SCHEMBL17131027 | 0.85 | SLC6A2 (0.37) | BRD4SLC6A2SLC6A4SLC6A3ADRB2 | |
| SCHEMBL1260402 | 0.85 | SLC6A2 (0.37) | BRD4SLC6A2SLC6A4SLC6A3ADRB2 | |
| SCHEMBL1413740 | 0.84 | EPHX1 (0.43) | BRD4SLC6A2SLC6A4SLC6A3ADRB2 | |
| SCHEMBL27833854 | 0.83 | SLC6A2 (0.38) | BRD4SLC6A2SLC6A4SLC6A3ADRB2 | |
| SCHEMBL10941630 | 0.83 | CASP2 (0.38) | BRD4SLC6A2SLC6A4SLC6A3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802902-A1 | INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF OSTEOPOROSIS | Smithkline Beecham S.p.A. (IT) | 1997-10-29 | — | — | EP | disclosed |