Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 9/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 6/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.37 |
| ▸ | RELA | Q04206 | 6/20 | 0.37 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 3/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | FCER2 | P06734 | 1/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.32 |
| ▸ | MASP2 | O00187 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789058 | 0.96 | NPY1R (0.39) | PSMB5CTSSCTSKNFKB1NFKB2 | |
| SCHEMBL8790274 | 0.93 | PSMB5 (0.39) | PSMB5CTSSCTSKNFKB1NFKB2 | |
| SCHEMBL8790284 | 0.93 | PSMB5 (0.39) | PSMB5CTSSCTSKNFKB1NFKB2 | |
| SCHEMBL8791513 | 0.89 | CTSS (0.40) | CTSSMMP1F2 | |
| SCHEMBL8789381 | 0.89 | NPY1R (0.41) | PSMB5NFKB1NFKB2RELANPY1R | |
| SCHEMBL8789373 | 0.89 | NPY1R (0.41) | PSMB5NFKB1NFKB2RELANPY1R | |
| SCHEMBL8790228 | 0.87 | PSMB5 (0.41) | PSMB5CTSSCTSKNFKB1NFKB2 | |
| SCHEMBL9421660 | 0.86 | PSMB5 (0.44) | PSMB5CTSSCTSKNFKB1NFKB2 | |
| SCHEMBL9421695 | 0.85 | CTSS (0.39) | PSMB5CTSSCTSKNFKB1NFKB2 | |
| SCHEMBL8789119 | 0.85 | MAPT (0.44) | CTSSCTSKMMP8MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0669830-A4 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1997-02-26 | — | — | EP | claimed |
| EP-0669830-A1 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-09-06 | — | — | EP | claimed |
| WO-1994011012-A1 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-05-26 | — | — | WO | claimed |
| WO-1994011012-A1 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-05-26 | — | — | WO | disclosed |