Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789820 | 0.94 | KDM4E (0.46) | KDM4ECYP1A2CYP3A4CYP2D6BLM | |
| SCHEMBL8790366 | 0.85 | TSHR (0.53) | KDM4ECYP1A2CYP3A4CYP2D6BLM | |
| SCHEMBL8790671 | 0.84 | KDM4E (0.48) | KDM4ECYP1A2CYP3A4CYP2D6BLM | |
| SCHEMBL8790592 | 0.83 | CYP3A4 (0.64) | KDM4ECYP1A2CYP3A4CYP2D6BLM | |
| SCHEMBL8790572 | 0.81 | ALDH1A1 (0.50) | KDM4ECYP1A2CYP3A4CYP2D6BLM | |
| SCHEMBL8791130 | 0.81 | ALDH1A1 (0.54) | KDM4ECYP1A2CYP3A4CYP2D6BLM | |
| SCHEMBL8789780 | 0.81 | KDM4E (0.45) | KDM4ECYP1A2CYP3A4CYP2D6BLM | |
| SCHEMBL8790500 | 0.79 | CYP19A1 (0.51) | KDM4ECYP1A2CYP3A4CYP2D6BLM | |
| SCHEMBL8791027 | 0.76 | NR1H3 (0.51) | KDM4ECYP1A2CYP3A4CYP2D6BLM | |
| SCHEMBL8790748 | 0.76 | KCNH2 (0.50) | KDM4ECYP1A2CYP3A4CYP2D6BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |