SCHEMBL8790405

SCHEMBL8790405

CCCCc1nc2ccc(C3=NNC(=O)CC3)cc2n1Cc1ccc(-c2ccccc2OC(=O)OC)cc1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 1/20 0.48
AGTR2 P50052 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8789632 0.96 PPARG (0.52)
SCHEMBL8788968 0.93 AGTR1 (0.51) AGTR1AGTR2
SCHEMBL8789199 0.93 PPARG (0.44) AGTR1
SCHEMBL9096908 0.88 AGTR1 (0.55) AGTR1AGTR2
SCHEMBL8789986 0.88 PPARG (0.54)
SCHEMBL9096876 0.86 AGTR1 (0.67) AGTR1AGTR2
SCHEMBL8788943 0.85 PPARG (0.46)
SCHEMBL9098205 0.84 PPARG (0.59)
SCHEMBL7299049 0.82 AGTR1 (0.47) AGTR1AGTR2
SCHEMBL9096321 0.81 PPARG (0.70)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0468470-B1 Benzimidazoles, medicaments containing them and process for their preparation THOMAE GMBH DR K (DE) 1997-04-16 EP disclosed
EP-0468470-A1 Benzimidazoles, medicaments containing them and process for their preparation Dr. Karl Thomae GmbH (DE) 1992-01-29 EP disclosed