Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790797 | 0.85 | ALDH1A1 (0.47) | ALDH1A1HPGDMAPK8MAPK10KDM4C | |
| SCHEMBL8790827 | 0.80 | ALDH1A1 (0.38) | ALDH1A1HPGDKDM4CMAPTGAA | |
| SCHEMBL8791772 | 0.79 | KDM4E (0.48) | ALDH1A1HPGDKDM4CHDAC3HDAC1 | |
| SCHEMBL8791432 | 0.78 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPK8MAPK10KDM4C | |
| SCHEMBL8790955 | 0.74 | ALDH1A1 (0.51) | ALDH1A1HPGDMAPK8MAPK10KDM4C | |
| SCHEMBL8791123 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HPGDMAPK8MAPK10KDM4C | |
| SCHEMBL8791721 | 0.72 | ALDH1A1 (0.46) | ALDH1A1HPGDMAPK8MAPK10KDM4C | |
| SCHEMBL8791490 | 0.72 | ALDH1A1 (0.41) | ALDH1A1HPGDMAPK8MAPK10KDM4C | |
| SCHEMBL8792739 | 0.71 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPK8MAPK10KDM4C | |
| SCHEMBL8790045 | 0.69 | KMT2A (0.63) | ALDH1A1HPGDKDM4CHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| EP-0421365-A2 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |