Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 6/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790687 | 0.83 | ALDH1A1 (0.67) | HPGDSMN1; SMN2L3MBTL1HSD17B10 | |
| SCHEMBL3708995 | 0.81 | HPGD (0.65) | POLBHPGDTSHRKLK7SMN1; SMN2 | |
| SCHEMBL8790945 | 0.80 | POLB (0.45) | POLBHPGDTSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL13402902 | 0.80 | POLB (0.45) | POLBHPGDTSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL13631426 | 0.79 | HPGD (0.71) | POLBHPGDTSHRKLK7SMN1; SMN2 | |
| SCHEMBL12195579 | 0.77 | HPGD (0.63) | POLBHPGDTSHRKLK7SMN1; SMN2 | |
| SCHEMBL423503 | 0.76 | HTT (0.60) | POLBHPGDTSHRKLK7SMN1; SMN2 | |
| SCHEMBL30911235 | 0.76 | HTT (0.60) | POLBHPGDTSHRKLK7SMN1; SMN2 | |
| SCHEMBL8791581 | 0.76 | ALDH1A1 (0.48) | POLBHPGDTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL22819344 | 0.75 | HPGD (0.65) | POLBHPGDTSHRKLK7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-RE35321-E | ANTIDIABETIC AGENT | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| EP-0421365-A2 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |