Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 8/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 8/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.30 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790767 | 0.92 | HSD11B1 (0.34) | HSD11B1 | |
| Oxalic Acid SCHEMBL8791269 | 0.90 | CHRM2 (0.43) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL8790272 | 0.88 | CHRM2 (0.45) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL8791563 | 0.87 | CHRM2 (0.46) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL8791078 | 0.86 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL8791341 | 0.84 | — | — | |
| Oxalic Acid SCHEMBL8791335 | 0.84 | — | — | |
| Oxalic Acid SCHEMBL8790622 | 0.83 | HSD11B1 (0.41) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL8790669 | 0.81 | CHRM2 (0.36) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL9879691 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413545-B1 | Azabicyclic compounds | BEECHAM GROUP PLC (GB) | 1997-05-14 | — | — | EP | disclosed |
| US-5157160-A | Treatment of diseases of the nervous system | BEECHAM GROUP P.L.C. (GB) | 1992-10-20 | — | — | US | disclosed |
| EP-0413545-A2 | Azabicyclic compounds | Beecham Group p.l.c. (GB) | 1991-02-20 | — | — | EP | disclosed |