SCHEMBL8790982

SCHEMBL8790982

COC(=O)C1(CCCCl)CNC1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 1/20 0.44
CYP4A11 Q02928 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL356203 0.76 CYP4F2 (0.49) CYP4F2CYP4A11
SCHEMBL20601941 0.76 CYP4F2 (0.49) CYP4F2CYP4A11
SCHEMBL6268373 0.75 CYP4F2 (0.70) CYP4F2CYP4A11
SCHEMBL19797415 0.75 CYP4F2 (0.38) CYP4F2CYP4A11
SCHEMBL9886223 0.71 CYP4F2 (0.51) CYP4F2CYP4A11
SCHEMBL25329101 0.69 CYP4F2 (0.33) CYP4F2CYP4A11
SCHEMBL9959154 0.68 CYP4F2 (0.44) CYP4F2CYP4A11
SCHEMBL22208201 0.68 ARG1 (0.44) CYP4F2CYP4A11
SCHEMBL24866607 0.67 CYP4F2 (0.30) CYP4F2CYP4A11
Hydrochloric Acid SCHEMBL26120445 0.67 CYP4F2 (0.33) CYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0413545-B1 Azabicyclic compounds BEECHAM GROUP PLC (GB) 1997-05-14 EP disclosed
US-5157160-A Treatment of diseases of the nervous system BEECHAM GROUP P.L.C. (GB) 1992-10-20 US disclosed
US-5043343-A Certain 5-substituted-1-aza-bicyclo[3.3.3]heptanes and their pharmaceutical compositions and methods BEECHAM GROUP P.L.C. (GB) 1991-08-27 US disclosed
EP-0413545-A2 Azabicyclic compounds Beecham Group p.l.c. (GB) 1991-02-20 EP disclosed