Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 14/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 10/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 11/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791793 | 0.95 | ADRB3 (0.51) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL8792395 | 0.93 | SERPINE1 (0.51) | ADRB3ADRB1ADRB2 | |
| SCHEMBL8700162 | 0.92 | ADRB3 (0.55) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL8700159 | 0.92 | ADRB3 (0.55) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL8697010 | 0.92 | ADRB3 (0.55) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL8791031 | 0.92 | ADRB2 (0.48) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL8792108 | 0.91 | ADRB3 (0.54) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL8791714 | 0.91 | ADRB3 (0.51) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL8700180 | 0.90 | ADRB3 (0.60) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL8700182 | 0.90 | ADRB3 (0.60) | ADRB3ADRB1ADRB2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703911-B1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER (US) | 1997-07-02 | — | — | EP | disclosed |
| EP-0703911-A1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029290-A1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER INC. (US) | 1994-12-22 | — | — | WO | disclosed |