Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BRS3 | P32247 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12606476 | 0.89 | SLC6A3 (0.68) | SLC6A3SLC6A4SLC6A2ROCK2CSF1R | |
| SCHEMBL29978969 | 0.88 | SLC6A3 (0.71) | SLC6A3SLC6A4SLC6A2ROCK2CSF1R | |
| SCHEMBL6797969 | 0.88 | SLC6A3 (0.71) | SLC6A3SLC6A4SLC6A2ROCK2CSF1R | |
| SCHEMBL27641566 | 0.85 | SLC6A3 (0.48) | SLC6A3SLC6A4SLC6A2BDKRB1KDM4E | |
| SCHEMBL14855856 | 0.84 | SLC6A3 (0.47) | SLC6A3SLC6A4SLC6A2BDKRB1BRS3 | |
| SCHEMBL23354048 | 0.83 | SLC6A3 (0.69) | SLC6A3SLC6A4SLC6A2ROCK2CSF1R | |
| SCHEMBL29979249 | 0.83 | SLC6A3 (0.69) | SLC6A3SLC6A4SLC6A2ROCK2CSF1R | |
| SCHEMBL8855194 | 0.81 | SLC6A3 (0.62) | SLC6A3SLC6A4SLC6A2ROCK2CSF1R | |
| SCHEMBL9125043 | 0.81 | SLC6A3 (0.97) | SLC6A3SLC6A4SLC6A2ROCK2CSF1R | |
| SCHEMBL31318316 | 0.80 | SLC6A3 (0.78) | SLC6A3SLC6A4SLC6A2ROCK2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0324377-B1 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | DU PONT (US) | 1997-04-16 | — | — | EP | disclosed |
| EP-0324377-A2 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-19 | — | — | EP | disclosed |