Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 13/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.60 |
| ▸ | GCGR | P47871 | 13/20 | 0.60 |
| ▸ | RAF1 | P04049 | 3/20 | 0.55 |
| ▸ | TEK | Q02763 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8793359 | 0.86 | GCGR (0.59) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL8792567 | 0.85 | MAPK14 (0.64) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL8792477 | 0.85 | GCGR (0.52) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL8791623 | 0.84 | MAPK14 (0.62) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL6971736 | 0.84 | MAPK13 (0.62) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL27474617 | 0.84 | MAPK14 (0.62) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL8791844 | 0.83 | ALOX5 (0.55) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL5196177 | 0.83 | MAPK13 (0.64) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL5184633 | 0.82 | MAPK14 (0.70) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL8791555 | 0.82 | MAPK14 (0.74) | MAPK13MAPK12MAPK11MAPK14GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0797575-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-01 | — | — | EP | claimed |
| WO-1996018626-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-20 | — | — | WO | claimed |
| EP-0797575-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-01 | — | — | EP | disclosed |
| WO-1996018626-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-20 | — | — | WO | disclosed |