Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 10/20 | 0.71 |
| ▸ | PIM1 | P11309 | 8/20 | 0.66 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.60 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844836 | 0.88 | PIM3 (0.70) | PIM3PIM1PIM2TRIM24TRIM33 | |
| SCHEMBL845204 | 0.88 | PIM3 (0.70) | PIM3PIM1PIM2TRIM24TRIM33 | |
| SCHEMBL844520 | 0.87 | PIM3 (0.78) | PIM3PIM1PIM2TRIM24TRIM33 | |
| SCHEMBL844605 | 0.84 | PIM3 (0.64) | PIM3PIM1PIM2TRIM24TRIM33 | |
| SCHEMBL844626 | 0.83 | PIM3 (1.00) | PIM3PIM1PIM2TRIM24TRIM33 | |
| SCHEMBL844630 | 0.82 | PIM3 (0.57) | PIM3PIM1PIM2TRIM24TRIM33 | |
| SCHEMBL15330072 | 0.82 | ALDH1A1 (0.56) | PIM3PIM1TRIM24TRIM33ICMT | |
| SCHEMBL845188 | 0.81 | PIM3 (0.60) | PIM3PIM1PIM2ALDH1A1KDM4E | |
| SCHEMBL10079034 | 0.80 | PIM3 (0.71) | PIM3PIM1PIM2TRIM24TRIM33 | |
| SCHEMBL844850 | 0.80 | PIM3 (1.00) | PIM3PIM1PIM2TRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481586-B2 | Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-07-09 | — | — | US | disclosed |
| EP-2326649-B1 | NOVEL PYRROLO[2,3-a]CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | CENTRE NAT RECH SCIENT (FR) | 2012-03-28 | — | — | EP | disclosed |
| US-20110263669-A1 | Novel Pyrrolo [2,3-A] Carbazoles and Use Thereof as PIM Kinase Inhibitors | UNIVERSITE BLAISE PASCAL-CLERMONT-FERRAND II (FR) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263669-A1 | Novel Pyrrolo [2,3-A] Carbazoles and Use Thereof as PIM Kinase Inhibitors | PIM3, PIM1, PIM2 | PIM3 1/4885PIM1 2/4885PIM2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.