SCHEMBL8793385

SCHEMBL8793385

CC(C)Cc1ccc(C(C)Nc2cccc(C(=O)c3cn(CCCC(=O)O)c4ccccc34)c2)cc1

nearest known ligand 0.88

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 6/20 0.88
SRD5A2 P31213 6/20 0.88
CNR1 P21554 3/20 0.49
CNR2 P34972 2/20 0.49
MAPT P10636 2/20 0.43
POLB P06746 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29633452 0.93 SRD5A1 (1.00) SRD5A1SRD5A2CNR1CNR2MAPT
SCHEMBL3504489 0.93 SRD5A1 (1.00) SRD5A1SRD5A2CNR1CNR2MAPT
Hydrochloric Acid SCHEMBL8793978 0.93 SRD5A1 (0.98) SRD5A1SRD5A2CNR1CNR2MAPT
SCHEMBL9336300 0.91 SRD5A1 (0.86) SRD5A1SRD5A2CNR1CNR2MAPT
SCHEMBL8793523 0.91 SRD5A1 (0.95) SRD5A1SRD5A2CNR1CNR2MAPT
SCHEMBL8794139 0.91 SRD5A1 (0.73) SRD5A1SRD5A2CNR1CNR2MAPT
SCHEMBL9337733 0.90 SRD5A1 (0.81) SRD5A1SRD5A2CNR1CNR2MAPT
SCHEMBL9335715 0.90 SRD5A1 (0.81) SRD5A1SRD5A2CNR1CNR2MAPT
SCHEMBL9337867 0.90 SRD5A1 (0.84) SRD5A1SRD5A2CNR1CNR2MAPT
N-Phenylbenzamide SCHEMBL6762152 0.89 SRD5A1 (0.91) SRD5A1SRD5A2CNR1CNR2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0458207-B1 Indole derivatives FUJISAWA PHARMACEUTICAL CO (JP) 1997-03-26 EP disclosed
CN-1030701-C Indole derivatives and process for production thereof FUJISAWA PHARMACEUTICAL CO (JP) 1996-01-17 CN disclosed
US-5312829-A Testosterone 5alpha-reductase inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-17 US disclosed
US-5212320-A Enzyme inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-05-18 US disclosed
EP-0458207-A2 Indole derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-11-27 EP disclosed