Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8792583 | 0.89 | HTT (0.51) | KMT2APOLBHTTSMN1; SMN2MEN1 | |
| SCHEMBL9870642 | 0.72 | LMNA (0.44) | KMT2APOLBNPC1RAB9AKDM4E | |
| SCHEMBL21637228 | 0.69 | NPC1 (0.58) | KMT2APOLBHTTSMN1; SMN2NPC1 | |
| SCHEMBL10674326 | 0.68 | NPC1 (0.46) | KMT2AHTTNPC1RAB9AKDM4E | |
| SCHEMBL29640450 | 0.67 | RXFP1 (0.73) | KMT2APOLBKDM4ERXFP1 | |
| SCHEMBL5618599 | 0.67 | KMT2A (0.53) | KMT2APOLBHTTSMN1; SMN2RXFP1 | |
| SCHEMBL10677336 | 0.67 | NPC1 (0.47) | KMT2ANPC1RAB9AKDM4ERXFP1 | |
| SCHEMBL5619568 | 0.66 | HTT (0.55) | KMT2APOLBHTTSMN1; SMN2NPC1 | |
| SCHEMBL5618934 | 0.66 | DPP4 (0.62) | KMT2APOLBNPC1RAB9ADPP4 | |
| SCHEMBL18126714 | 0.66 | DPP4 (0.64) | KMT2APOLBHTTSMN1; SMN2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441339-A1 | Substituted triazolopyridazines | MERRELL PHARMACEUTICALS INC. (US) | 1991-08-14 | — | — | EP | claimed |
| EP-0797576-A1 | ALKYL SUBSTITUTED PIPERADINYL AND PIPERAZINYL ANTI-AIDS COMPOUNDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-10-01 | — | — | EP | disclosed |
| EP-0441339-B1 | Substituted triazolopyridazines | MERRELL PHARMA INC (US) | 1997-08-20 | — | — | EP | disclosed |
| EP-0441339-A1 | Substituted triazolopyridazines | MERRELL PHARMACEUTICALS INC. (US) | 1991-08-14 | — | — | EP | disclosed |
| US-5011835-A | Substituted triazolopyridazines, pharmaceutical compositions and use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-30 | — | — | US | disclosed |