Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796099 | 0.84 | GRIN2D (0.50) | MTNR1AMTNR1BALDH1A1HPGDKDM4E | |
| SCHEMBL8794843 | 0.75 | KDM4E (0.53) | ALDH1A1HPGDKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL8795329 | 0.74 | GRIN2D (0.36) | GRIA1CACNG8GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5473245 | 0.72 | NQO2 (0.54) | MTNR1AMTNR1BALDH1A1HPGDKDM4E | |
| SCHEMBL8794931 | 0.72 | KDM4E (0.48) | HPGDKDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL8794489 | 0.72 | PARP1 (0.49) | ALDH1A1HPGDKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL8794516 | 0.72 | NQO2 (0.50) | ALDH1A1HPGDKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL10619036 | 0.70 | KMO (0.45) | MTNR1AMTNR1BALDH1A1HPGDKDM4E | |
| SCHEMBL15428090 | 0.70 | NCOA1 (0.73) | MTNR1AMTNR1BALDH1A1HPGDKDM4E | |
| SCHEMBL8796139 | 0.69 | ABCG2 (0.54) | MTNR1AMTNR1BALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652239-A | TREATMENT OF STROKES, ISCHEMIC ATTACK, ANTAGONISTS OF EXCITATORY AMINO ACIDS GLUTAMATE AND ASPARTATE | IMPERIAL CHEMICAL COMPANY (GB) | 1997-07-29 | — | — | US | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |