Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.37 |
| ▸ | MDH1 | P40925 | 2/20 | 0.37 |
| ▸ | MDH2 | P40926 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8794991 | 1.00 | PLA2G4A (0.42) | PLA2G4AHIF1AEPAS1MDH1MDH2 | |
| SCHEMBL8795834 | 0.89 | PLA2G4A (0.40) | PLA2G4APOLBSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8795840 | 0.89 | PLA2G4A (0.40) | PLA2G4APOLBSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8795818 | 0.86 | PLA2G4A (0.47) | PLA2G4AHIF1AEPAS1MDH1MDH2 | |
| SCHEMBL8795811 | 0.86 | PLA2G4A (0.47) | PLA2G4AHIF1AEPAS1MDH1MDH2 | |
| SCHEMBL9259400 | 0.83 | PLA2G4A (0.41) | PLA2G4AHIF1AEPAS1EPHX2ALDH1A1 | |
| SCHEMBL8795615 | 0.82 | PLA2G4A (0.48) | PLA2G4AHIF1AEPAS1MDH1MDH2 | |
| SCHEMBL8795603 | 0.82 | PLA2G4A (0.48) | PLA2G4AHIF1AEPAS1MDH1MDH2 | |
| SCHEMBL8796646 | 0.81 | CYP3A4 (0.41) | PLA2G4ARARARARBRARGCYP4F2 | |
| SCHEMBL8796651 | 0.81 | CYP3A4 (0.41) | PLA2G4ARARARARBRARGCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |