Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | TP53 | P04637 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169942 | 1.00 | TSHR (0.72) | TSHRALDH1A1TP53SMN1; SMN2HIF1A | |
| SCHEMBL19828239 | 0.85 | ALDH1A1 (0.74) | TSHRALDH1A1TP53SMN1; SMN2HIF1A | |
| SCHEMBL37802 | 0.84 | ALDH1A1 (1.00) | TSHRALDH1A1TP53SMN1; SMN2HIF1A | |
| SCHEMBL31537002 | 0.84 | ALDH1A1 (1.00) | TSHRALDH1A1TP53SMN1; SMN2HIF1A | |
| SCHEMBL31537008 | 0.84 | ALDH1A1 (1.00) | TSHRALDH1A1TP53SMN1; SMN2HIF1A | |
| SCHEMBL12289601 | 0.84 | ALDH1A1 (1.00) | TSHRALDH1A1TP53SMN1; SMN2HIF1A | |
| SCHEMBL13806572 | 0.84 | ALDH1A1 (1.00) | TSHRALDH1A1TP53SMN1; SMN2HIF1A | |
| SCHEMBL16527504 | 0.84 | ALDH1A1 (0.72) | TSHRALDH1A1TP53SMN1; SMN2HIF1A | |
| SCHEMBL22855755 | 0.84 | ALDH1A1 (0.72) | TSHRALDH1A1TP53SMN1; SMN2HIF1A | |
| SCHEMBL27697987 | 0.84 | ALDH1A1 (0.72) | TSHRALDH1A1TP53SMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611003-B1 | Substituted phenyl sulfonamides as selective B3 agonists for the treatment of diabetes and obesity | MERCK & CO INC (US) | 1997-06-18 | — | — | EP | disclosed |
| US-5451677-A | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity | MERCK & CO., INC. (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0611003-A1 | Substituted phenyl sulfonamides as selective B3 agonists for the treatment of diabetes and obesity | MERCK & CO. INC. (US) | 1994-08-17 | — | — | EP | disclosed |