Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ACP3 | P15309 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795367 | 1.00 | PLA2G4A (0.40) | PLA2G4ARXRARXRBRXRGCYP26B1 | |
| SCHEMBL8796319 | 0.87 | CYP26B1 (0.47) | PLA2G4ARXRARXRBRXRGCYP26B1 | |
| SCHEMBL8796315 | 0.87 | CYP26B1 (0.47) | PLA2G4ARXRARXRBRXRGCYP26B1 | |
| SCHEMBL8796322 | 0.87 | CYP26B1 (0.47) | PLA2G4ARXRARXRBRXRGCYP26B1 | |
| SCHEMBL8795259 | 0.86 | PLA2G4A (0.43) | PLA2G4ARXRARXRBRXRGCYP26B1 | |
| SCHEMBL8795256 | 0.86 | PLA2G4A (0.43) | PLA2G4ARXRARXRBRXRGCYP26B1 | |
| SCHEMBL8795252 | 0.86 | PLA2G4A (0.43) | PLA2G4ARXRARXRBRXRGCYP26B1 | |
| SCHEMBL8796087 | 0.86 | PLA2G4A (0.42) | PLA2G4ARXRARXRBRXRGCYP26B1 | |
| SCHEMBL8796080 | 0.86 | PLA2G4A (0.42) | PLA2G4ARXRARXRBRXRGCYP26B1 | |
| SCHEMBL8795910 | 0.86 | PLA2G4A (0.42) | PLA2G4ARXRARXRBRXRGCYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0629604-A2 | Alicyclic phospholipase A2 inhibitors | Bristol-Myers Company (US) | 1994-12-21 | — | — | EP | disclosed |