Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15787043 | 1.00 | AR (0.42) | ARSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL15787042 | 1.00 | AR (0.42) | ARSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL6112960 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9AGAANPC1LMNA | |
| SCHEMBL6112957 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9AGAANPC1LMNA | |
| SCHEMBL8401230 | 0.81 | GAA (0.49) | ARSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL6112826 | 0.81 | GAA (0.49) | ARSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL6112830 | 0.81 | GAA (0.49) | ARSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL12877698 | 0.79 | AR (0.47) | ARSMN1; SMN2TDP1LMNAMEN1 | |
| SCHEMBL8795679 | 0.74 | AR (0.45) | ARSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL10066804 | 0.73 | AR (0.44) | ARSMN1; SMN2GAATDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754112-B2 | Sulfone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-06-17 | — | — | US | disclosed |
| US-8754112-B2 | Sulfone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-06-17 | — | — | US | disclosed |
| EP-2468737-B1 | SULFONE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2013-10-30 | — | — | EP | disclosed |
| EP-2468737-A1 | SULFONE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-06-27 | — | — | EP | disclosed |
| US-20120129891-A1 | SULFONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-05-24 | — | — | US | disclosed |
| US-20120129891-A1 | SULFONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-05-24 | — | — | US | disclosed |
| WO-2011016470-A1 | SULFONE DERIVATIVE | 第一三共株式会社 (JP) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129891-A1 | SULFONE DERIVATIVE | SLC5A1, SLC5A2, SLC2A1 | AR 3625/4885SMN1; SMN2 286/4885RAB9A 1319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.