SCHEMBL8795545

SCHEMBL8795545

[CH2]C[Si](CC)(CCCC)CCCC

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.32
LMNA P02545 1/20 0.32
THRB P10828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28285913 0.88 TSHR (0.35) TSHRLMNATHRB
SCHEMBL5833911 0.82 TSHR (0.40) TSHRLMNATHRB
SCHEMBL27093756 0.82 TSHR (0.40) TSHRLMNATHRB
SCHEMBL6671712 0.82 TSHR (0.40) TSHRLMNATHRB
SCHEMBL27943105 0.77 TSHR (0.35) TSHRLMNATHRB
SCHEMBL27943175 0.77 TSHR (0.35) TSHRLMNATHRB
SCHEMBL434505 0.75 TSHR (0.46) TSHRLMNATHRB
SCHEMBL197112 0.75
SCHEMBL2144498 0.74 TSHR (0.33) TSHRLMNATHRB
SCHEMBL28287319 0.74 TSHR (0.33) TSHRLMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0669830-A4 SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE. MERCK & CO INC (US) 1997-02-26 EP claimed
EP-0669830-A1 SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO. INC. (US) 1995-09-06 EP claimed
EP-0746320-A4 HIV PROTEASE INHIBITORS AND INTERMEDIATES LILLY CO ELI (US) 1997-06-11 EP disclosed
EP-0741719-A4 INTERMEDIATE AND PROCESS FOR MAKING LILLY CO ELI (US) 1997-04-02 EP disclosed
EP-0746320-A1 HIV PROTEASE INHIBITORS AND INTERMEDIATES ELI LILLY AND COMPANY (US) 1996-12-11 EP disclosed
EP-0741719-A1 INTERMEDIATE AND PROCESS FOR MAKING ELI LILLY AND COMPANY (US) 1996-11-13 EP disclosed
WO-1995021164-A1 INTERMEDIATE AND PROCESS FOR MAKING ELI LILLY AND COMPANY (US) 1995-08-10 WO disclosed