Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12185449 | 0.94 | EGFR (0.54) | EGFRSYKJAK2PLK4HDAC1 | |
| SCHEMBL12185447 | 0.90 | PAK1 (0.44) | EGFRHDAC1CCNT1CDK9PAK4 | |
| SCHEMBL12185464 | 0.90 | PAK1 (0.44) | EGFRHDAC1CCNT1CDK9PAK4 | |
| SCHEMBL3392875 | 0.87 | NMT1 (0.44) | EGFRHDAC1PAK4PAK1ABL1 | |
| SCHEMBL12185450 | 0.86 | KDR (0.57) | EGFRSYKJAK2PLK4CDK9 | |
| SCHEMBL12185480 | 0.86 | EGFR (0.55) | EGFRSYKHDAC1IGF1RPAK4 | |
| SCHEMBL12185296 | 0.86 | EGFR (0.49) | EGFRSYKJAK2ABL1SRC | |
| SCHEMBL12185474 | 0.84 | CCNT1 (0.46) | SYKCCNT1CDK9PAK4PAK1 | |
| SCHEMBL6258964 | 0.81 | SYK (0.47) | EGFRSYKPLK4HRH3IGF1R | |
| SCHEMBL12185751 | 0.80 | EPHB4 (0.48) | EGFRJAK2CCNT1CDK9CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433636-A1 | Treatment of Malignant Diseases | Medizinische Universität Wien (AT) | 2012-03-28 | — | — | EP | disclosed |