Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.73 |
| ▸ | MEN1 | O00255 | 4/20 | 0.73 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | PPIA | P62937 | 2/20 | 0.67 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.66 |
| ▸ | SCN1A | P35498 | 1/20 | 0.66 |
| ▸ | SCN4A | P35499 | 1/20 | 0.66 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.66 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.66 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.66 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.66 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11912010 | 0.85 | MEN1 (0.70) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| SCHEMBL1102011 | 0.84 | KMT2A (0.76) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| SCHEMBL1102252 | 0.84 | KMT2A (1.00) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| Maleylsulfathiazole SCHEMBL29366629 | 0.81 | MEN1 (0.72) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| Succinylsulfathiazole SCHEMBL151873 | 0.81 | LMNA (1.00) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| SCHEMBL10031625 | 0.81 | KMT2A (0.71) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| SCHEMBL27371334 | 0.81 | PPIA (0.80) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| SCHEMBL1091178 | 0.81 | LMNA (0.74) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| SCHEMBL1101958 | 0.81 | MEN1 (0.75) | KMT2AMEN1TSHRSMN1; SMN2LMNA | |
| SCHEMBL11912014 | 0.81 | KMT2A (0.77) | KMT2AMEN1SMN1; SMN2SCN3ASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934191-B1 | BIPHENYL DERIVATIVES AS MODULATORS OF VOLTAGE GATED ION CHANNELS | VERTEX PHARMA (US) | 2012-03-28 | — | — | EP | disclosed |