Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 3/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 3/20 | 0.36 |
| ▸ | RARG | P13631 | 3/20 | 0.36 |
| ▸ | RARA | P10276 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795983 | 1.00 | PLA2G4A (0.46) | PLA2G4ANQO2POLBKDM4EMAPT | |
| SCHEMBL8796153 | 0.84 | PLA2G4A (0.51) | PLA2G4ANQO2POLBKDM4ERARB | |
| SCHEMBL8796157 | 0.84 | PLA2G4A (0.51) | PLA2G4ANQO2POLBKDM4ERARB | |
| SCHEMBL8796190 | 0.83 | PLA2G4A (0.48) | PLA2G4ANQO2POLBKDM4EMAPT | |
| SCHEMBL8796204 | 0.83 | PLA2G4A (0.48) | PLA2G4ANQO2POLBKDM4EMAPT | |
| SCHEMBL8796110 | 0.82 | PLA2G4A (0.46) | PLA2G4ANQO2POLBKDM4EMAPT | |
| SCHEMBL8795959 | 0.82 | PLA2G4A (0.60) | PLA2G4ANQO2POLBKDM4EMAPT | |
| SCHEMBL8795946 | 0.82 | PLA2G4A (0.60) | PLA2G4ANQO2POLBKDM4EMAPT | |
| SCHEMBL8795740 | 0.81 | PLA2G4A (0.53) | PLA2G4ANQO2POLBKDM4EMAPT | |
| SCHEMBL9259750 | 0.81 | PLA2G4A (0.53) | PLA2G4ANQO2POLBKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0629604-A2 | Alicyclic phospholipase A2 inhibitors | Bristol-Myers Company (US) | 1994-12-21 | — | — | EP | disclosed |