Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.55 |
| ▸ | RARG | P13631 | 13/20 | 0.55 |
| ▸ | RARA | P10276 | 11/20 | 0.55 |
| ▸ | RARB | P10826 | 11/20 | 0.55 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796227 | 1.00 | RXRA (0.55) | RXRARARGRARARARBCYP26A1 | |
| SCHEMBL8796223 | 1.00 | RXRA (0.55) | RXRARARGRARARARBCYP26A1 | |
| SCHEMBL6950912 | 0.86 | RXRA (0.56) | RXRARARGRARARARBCYP26A1 | |
| SCHEMBL6950903 | 0.86 | RXRA (0.56) | RXRARARGRARARARBCYP26A1 | |
| SCHEMBL6257239 | 0.86 | RXRA (0.56) | RXRARARGRARARARBCYP26A1 | |
| Bromide SCHEMBL9064208 | 0.83 | RXRA (0.53) | RXRARARGRARARARBCYP26A1 | |
| Bromide SCHEMBL9064204 | 0.83 | RXRA (0.53) | RXRARARGRARARARBCYP26A1 | |
| SCHEMBL8845976 | 0.82 | RARG (0.58) | RXRARARGRARARARBCYP26A1 | |
| SCHEMBL8845981 | 0.82 | RARG (0.58) | RXRARARGRARARARBCYP26A1 | |
| SCHEMBL8904248 | 0.82 | RXRA (0.61) | RXRARARGRARARARBCYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0629604-A2 | Alicyclic phospholipase A2 inhibitors | Bristol-Myers Company (US) | 1994-12-21 | — | — | EP | disclosed |