Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | MMP1 | P03956 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938099 | 0.86 | LDHA (0.60) | TUBB1LDHAPPARDPPARAPRSS1 | |
| SCHEMBL6933180 | 0.84 | TUBB1 (0.67) | TUBB1LMNAMAPK1HTTRAB9A | |
| SCHEMBL6933178 | 0.84 | TUBB1 (0.67) | TUBB1LMNAMAPK1HTTRAB9A | |
| SCHEMBL11861762 | 0.76 | PRSS1 (0.52) | LDHAPPARDPPARAPPARGPRSS1 | |
| SCHEMBL15570321 | 0.75 | LDHA (0.56) | TUBB1LDHAPPARDPPARAMMP1 | |
| SCHEMBL8012680 | 0.74 | LDHA (0.59) | LDHAPPARGLMNAMAPK1HTT | |
| SCHEMBL15881661 | 0.74 | LDHA (0.55) | TUBB1LDHALMNAMAPK1HTT | |
| SCHEMBL31329364 | 0.74 | LDHA (0.59) | LDHAPPARGLMNAMAPK1HTT | |
| SCHEMBL5986172 | 0.74 | LDHA (0.68) | LDHAMMP1LMNAMAPK1HTT | |
| SCHEMBL28741565 | 0.74 | LDHA (0.59) | LDHAPPARGLMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723442-A4 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS INC (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0723442-A1 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS, INC. (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1996003987-A1 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS, INC. (US) | 1996-02-15 | — | — | WO | disclosed |