Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520053 | 0.87 | EGFR (0.56) | EGFRPDGFRBMAPK1ABCG2FBP1 | |
| SCHEMBL8796440 | 0.87 | EGFR (0.53) | EGFRPDGFRBMAPK1ABCG2FBP1 | |
| SCHEMBL7523721 | 0.86 | EGFR (0.51) | EGFRPDGFRBMAPK1ABCG2FBP1 | |
| SCHEMBL7531093 | 0.85 | EGFR (0.50) | EGFRPDGFRBMAPK1ABCG2FBP1 | |
| SCHEMBL8796180 | 0.85 | EGFR (0.47) | EGFRPDGFRBMAPK1ABCG2FBP1 | |
| SCHEMBL7519922 | 0.85 | EGFR (0.58) | EGFRPDGFRBMAPK1ABCG2ALDH1A1 | |
| SCHEMBL7520151 | 0.85 | EGFR (0.53) | EGFRPDGFRBMAPK1ABCG2FBP1 | |
| SCHEMBL8796303 | 0.84 | EGFR (0.46) | EGFRPDGFRBMAPK1ABCG2FBP1 | |
| SCHEMBL8825686 | 0.84 | EGFR (0.52) | EGFRPDGFRBMAPK1ABCG2FBP1 | |
| SCHEMBL7517582 | 0.83 | EGFR (0.50) | EGFRPDGFRBMAPK1ABCG2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |