Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796180 | 0.91 | EGFR (0.47) | EGFRPDGFRBALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL8796308 | 0.86 | EGFR (0.47) | EGFRPDGFRBALDH1A1MAPTTDP1 | |
| SCHEMBL7514367 | 0.85 | MAPT (0.48) | EGFRPDGFRBALDH1A1MAPTTDP1 | |
| SCHEMBL8796332 | 0.84 | EGFR (0.50) | EGFRPDGFRBALDH1A1MAPK1FBP1 | |
| SCHEMBL7519162 | 0.82 | CYP1A2 (0.47) | EGFRPDGFRBALDH1A1MAPTMAPK1 | |
| SCHEMBL8795363 | 0.82 | PDGFRB (0.43) | EGFRPDGFRBALDH1A1MAPTMAPK1 | |
| SCHEMBL8070330 | 0.81 | ALDH1A1 (0.49) | EGFRALDH1A1MAPTMAPK1 | |
| SCHEMBL8796285 | 0.81 | SRC (0.47) | EGFRPDGFRBMAPK1 | |
| SCHEMBL7520053 | 0.81 | EGFR (0.56) | EGFRPDGFRBALDH1A1MAPK1FBP1 | |
| SCHEMBL8795326 | 0.81 | SRC (0.52) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |