Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 20/20 | 0.85 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.85 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL849020 | 0.94 | MAPK8 (0.89) | MAPK8MAPK9MAPK10 | |
| SCHEMBL848660 | 0.93 | MAPK8 (0.87) | MAPK8MAPK9MAPK10 | |
| SCHEMBL879620 | 0.92 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL847906 | 0.92 | MAPK8 (0.85) | MAPK8MAPK9MAPK10 | |
| SCHEMBL846967 | 0.90 | MAPK8 (0.81) | MAPK8MAPK9MAPK10 | |
| SCHEMBL846942 | 0.90 | MAPK8 (0.87) | MAPK8MAPK9MAPK10 | |
| SCHEMBL847361 | 0.89 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL846970 | 0.89 | MAPK8 (0.82) | MAPK8MAPK9MAPK10 | |
| SCHEMBL848656 | 0.88 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL31060971 | 0.88 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-B1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2012-03-28 | — | — | EP | disclosed |