Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28442240 | 0.73 | PNMT (0.42) | MAPTCA1CA2CA4CA6 | |
| SCHEMBL2763222 | 0.72 | PARP1 (0.70) | CA1CA2CA4CA6PARP1 | |
| SCHEMBL18337985 | 0.72 | KDR (0.42) | MAPTCA1CA2CA4CA6 | |
| SCHEMBL4954076 | 0.70 | CA1 (0.51) | CA1CA2CA4CA6KDR | |
| SCHEMBL27440875 | 0.70 | CA1 (0.54) | CA1CA2CA4CA6KDR | |
| SCHEMBL2359259 | 0.70 | KDR (0.41) | MAPTCA1CA2CA4CA6 | |
| SCHEMBL18337982 | 0.70 | MAP3K9 (0.41) | MAPTCA1CA2CA4CA6 | |
| SCHEMBL28444674 | 0.70 | KDR (0.41) | MAPTCA1CA2CA4CA6 | |
| SCHEMBL22159915 | 0.70 | PNMT (0.42) | MAPTKDRKDM4E | |
| SCHEMBL2359255 | 0.69 | MAP3K9 (0.41) | MAPTCA1CA2CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772612-A1 | 4-HYDROXY-3-PHENYL-INDENO(1,2-B)PYRIDINE-2(1H)-ONE DERIVATIVES AS NMDA ANTAGONISTS | Aventis Pharma S.A. (FR) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996002536-A1 | 4-HYDROXY-3-PHENYL-INDENO(1,2-B)PYRIDINE-2(1H)-ONE DERIVATIVES AS NMDA ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1996-02-01 | — | — | WO | disclosed |