Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825812 | 0.92 | KDM4E (0.53) | EGFRALDH1A1HPGDKDM4ECTSB | |
| SCHEMBL8796737 | 0.91 | EGFR (0.48) | EGFRALDH1A1HPGDKDM4ECTSB | |
| SCHEMBL7520053 | 0.86 | EGFR (0.56) | EGFRALDH1A1HPGDKDM4EPDGFRB | |
| SCHEMBL8796704 | 0.85 | EGFR (0.50) | EGFRALDH1A1HPGDKDM4EPDGFRB | |
| SCHEMBL8796440 | 0.85 | EGFR (0.53) | EGFRALDH1A1HPGDKDM4EPDGFRB | |
| SCHEMBL8827315 | 0.85 | EGFR (0.47) | EGFRALDH1A1HPGDKDM4ECTSB | |
| SCHEMBL8825813 | 0.84 | PKM (0.56) | EGFRALDH1A1HPGDKDM4EPDGFRB | |
| SCHEMBL8795549 | 0.83 | EGFR (0.52) | EGFRALDH1A1HPGDKDM4EPDGFRB | |
| SCHEMBL7519922 | 0.83 | EGFR (0.58) | EGFRALDH1A1HPGDKDM4EPDGFRB | |
| SCHEMBL7520151 | 0.83 | EGFR (0.53) | EGFRALDH1A1HPGDKDM4EPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |