SCHEMBL8796703

SCHEMBL8796703

Nc1ccc2c(c1)C(=O)N(CCOc1ccc(CC3SC(=O)NC3=O)cc1)CN2c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 13/20 0.49
PPARG P37231 7/20 0.49
HRH3 Q9Y5N1 1/20 0.47
MAPT P10636 1/20 0.46
PPARA Q07869 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8796710 0.91 FFAR1 (0.48) FFAR1PPARGHRH3MAPT
SCHEMBL8803015 0.91 FFAR1 (0.52) FFAR1PPARGHRH3MAPTPPARA
SCHEMBL8799688 0.87 FFAR1 (0.51) FFAR1PPARGHRH3PPARA
SCHEMBL8796706 0.84 HRH3 (0.38) FFAR1PPARGHRH3MAPT
SCHEMBL8796979 0.84 HRH3 (0.47) FFAR1PPARGHRH3MAPTPPARA
SCHEMBL8797295 0.80 FFAR1 (0.49) FFAR1PPARGHRH3MAPT
SCHEMBL8797128 0.79 HRH3 (0.50) FFAR1PPARGHRH3MAPTPPARA
SCHEMBL8796744 0.79 PPARG (0.55) FFAR1PPARGHRH3MAPTPPARA
SCHEMBL8796685 0.76 HRH3 (0.49) FFAR1PPARGHRH3MAPTPPARA
SCHEMBL8797315 0.76 FFAR1 (0.44) FFAR1PPARGHRH3MAPTPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787727-A1 Benzoazine derivative or salt thereof and pharmaceutical composition comprising the same SS Pharmaceutical Co., Ltd. (JP) 1997-08-06 EP disclosed