Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796668 | 0.87 | PTGS2 (0.57) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7832505 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL7846617 | 0.82 | PTGS2 (0.70) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7841787 | 0.80 | PTGS2 (0.80) | PTGS2PTGS1 | |
| SCHEMBL7845601 | 0.76 | PTGS2 (0.77) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7846621 | 0.75 | PTGS2 (0.60) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL11452546 | 0.73 | PTGS2 (0.73) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL6502554 | 0.70 | PTGS2 (0.51) | PTGS2PTGS1ALDH1A1KDM4ECDC7 | |
| SCHEMBL5698703 | 0.69 | PTGS2 (1.00) | PTGS2PTGS1ALDH1A1RXFP1KDM4E | |
| SCHEMBL7843084 | 0.69 | PTGS2 (0.85) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |