Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7481395 | 0.98 | DRD2 (0.58) | DRD2DRD4DRD3SIGMAR1LMNA | |
| SCHEMBL27563358 | 0.88 | — | — | |
| SCHEMBL3968181 | 0.88 | DRD2 (0.73) | DRD2DRD4DRD3SIGMAR1CCR2 | |
| SCHEMBL7682702 | 0.84 | DRD2 (0.64) | DRD2DRD4DRD3LMNAALDH1A1 | |
| SCHEMBL28770942 | 0.82 | DRD2 (0.62) | DRD2DRD4DRD3LMNAALDH1A1 | |
| SCHEMBL4827267 | 0.81 | DRD2 (0.60) | DRD2DRD4DRD3SIGMAR1CCR2 | |
| SCHEMBL260734 | 0.79 | DRD2 (0.63) | DRD2DRD4DRD3ALDH1A1CXCR4 | |
| SCHEMBL27804123 | 0.79 | DRD2 (0.63) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL28133126 | 0.79 | DRD2 (0.63) | DRD2DRD4DRD3LMNATDP1 | |
| SCHEMBL14375224 | 0.77 | DRD2 (0.55) | DRD2DRD4DRD3SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241053-B1 | ARYL-SUBSTITUTED (N-PIPERIDINYL)-METHYL- AND (N-PIPERAZINYL) METHYLAZOLES HAVING ANTIPSYCHOTIC PROPERTIES | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1992-11-11 | — | — | EP | claimed |
| CN-102558058-B | 1-aryl-3-substituent-5-substituted amino-4-pyrazole formamide compound and application thereof | SHAANXI SCIENCE AND ENGINEERING COLLEGE (CN) | 2014-10-29 | — | — | CN | disclosed |
| CN-102558058-A | 1-aryl-3-substituent-5-substituted amino-4-pyrazole formamide compound and application thereof | UNIV SHAANXI TECHNOLOGY | 2012-07-11 | — | — | CN | disclosed |
| EP-0691960-B1 | ANTIPSYCHOTIC BENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | disclosed |
| EP-0241053-B1 | ARYL-SUBSTITUTED (N-PIPERIDINYL)-METHYL- AND (N-PIPERAZINYL) METHYLAZOLES HAVING ANTIPSYCHOTIC PROPERTIES | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1992-11-11 | — | — | EP | disclosed |
| US-4874770-A | Aryl-substituted (N-piperidinyl)methyl- and (N-piperidinyl) methylazoles having antipsychotic properties | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1989-10-17 | — | — | US | disclosed |
| US-4772604-A | ANTIPSYCHOTIC AGENTS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1988-09-20 | — | — | US | disclosed |
| EP-0241053-A1 | Aryl-substituted (N-piperidinyl)-methyl- and (N-piperazinyl) methylazoles having antipsychotic properties | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1987-10-14 | — | — | EP | disclosed |
| EP-0241053-A1 | Aryl-substituted (N-piperidinyl)-methyl- and (N-piperazinyl) methylazoles having antipsychotic properties | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1987-10-14 | — | — | EP | disclosed |