Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 6/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 6/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797377 | 0.83 | TBXA2R (0.44) | TBXA2RTBXAS1MEN1CYP3A4MAPT | |
| SCHEMBL7508628 | 0.82 | HCRTR2 (0.38) | TBXA2RTBXAS1HCRTR2MEN1TP53 | |
| SCHEMBL5756737 | 0.80 | ATM (0.43) | TBXA2RTBXAS1LMNATP53MAPK1 | |
| SCHEMBL5756742 | 0.80 | ATM (0.43) | TBXA2RTBXAS1LMNATP53MAPK1 | |
| SCHEMBL8797251 | 0.80 | NOTUM (0.43) | TBXA2RTBXAS1 | |
| SCHEMBL8797835 | 0.80 | TP53 (0.38) | TBXA2RTBXAS1MEN1LMNATP53 | |
| SCHEMBL6938853 | 0.80 | TBXA2R (0.45) | TBXA2RTBXAS1 | |
| SCHEMBL8797275 | 0.80 | MAOB (0.44) | TBXA2RTBXAS1MAPT | |
| SCHEMBL8797894 | 0.80 | TBXA2R (0.40) | TBXA2RTBXAS1 | |
| SCHEMBL8797850 | 0.80 | KDM4E (0.42) | TBXA2RTBXAS1LMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |