Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797274 | 0.85 | TBXAS1 (0.45) | TBXA2RKMT2AMEN1MAPTGAA | |
| SCHEMBL8797301 | 0.84 | TBXA2R (0.39) | TBXA2RGAATBXAS1 | |
| SCHEMBL8797257 | 0.84 | KDM4E (0.41) | TBXA2RKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL5756742 | 0.84 | ATM (0.43) | TBXA2RGAATBXAS1TSHR | |
| SCHEMBL5756737 | 0.84 | ATM (0.43) | TBXA2RGAATBXAS1TSHR | |
| SCHEMBL6938853 | 0.83 | TBXA2R (0.45) | TBXA2RTBXAS1 | |
| SCHEMBL8797894 | 0.83 | TBXA2R (0.40) | TBXA2RTBXAS1 | |
| SCHEMBL8797251 | 0.83 | NOTUM (0.43) | TBXA2RGAATBXAS1 | |
| SCHEMBL8797275 | 0.83 | MAOB (0.44) | TBXA2RMAPTTBXAS1HTT | |
| SCHEMBL8797147 | 0.83 | TBXA2R (0.40) | TBXA2RKMT2AMEN1MAPTTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |