Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797482 | 0.90 | LPAR1 (0.45) | LPAR1TBXA2RLMNAKMT2ASOAT1 | |
| SCHEMBL8799023 | 0.89 | LPAR1 (0.38) | LPAR1TBXA2RLMNAKMT2ASOAT1 | |
| SCHEMBL8797662 | 0.84 | LPAR1 (0.46) | LPAR1TBXA2RLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8797449 | 0.82 | LPAR1 (0.44) | LPAR1TBXA2RLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8797883 | 0.82 | LPAR1 (0.46) | LPAR1TBXA2RLMNAKMT2ASOAT1 | |
| SCHEMBL8797028 | 0.82 | TBXA2R (0.38) | LPAR1TBXA2RLMNAKMT2A | |
| SCHEMBL8797886 | 0.80 | LPAR1 (0.42) | LPAR1TBXA2RLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8797373 | 0.79 | LPAR1 (0.44) | LPAR1TBXA2RLMNAKMT2ACCR5 | |
| SCHEMBL8797272 | 0.78 | TP53 (0.45) | LPAR1TBXA2RLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8613749 | 0.78 | LPAR1 (0.45) | LPAR1TBXA2RSOAT1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497201-B1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5478835-A | Acyl coenzyme A: acyltransferase inhibitors; treatment of hyperlipemia and arteriosclerosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5340807-A | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0497201-A1 | Tricyclic compounds and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-08-05 | — | — | EP | disclosed |