Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 1/20 | 0.57 |
| ▸ | ELOC | Q15369 | 1/20 | 0.57 |
| ▸ | ELOB | Q15370 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 5/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | GRK2 | P25098 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | AOC2 | O75106 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5601606 | 0.78 | VHL (0.57) | VHLELOCELOBPOLBNSD2 | |
| Hydrochloric Acid SCHEMBL21382427 | 0.77 | VHL (0.55) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL20319186 | 0.77 | VHL (0.67) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL2745550 | 0.75 | GFER (0.42) | KDM4EL3MBTL1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL5602418 | 0.75 | VHL (0.53) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL5603532 | 0.74 | MGLL (0.53) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL16242550 | 0.73 | VHL (0.61) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL1260586 | 0.73 | VHL (0.61) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL13461836 | 0.73 | VHL (0.61) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL5603565 | 0.73 | VHL (0.61) | VHLELOCELOBPOLBNSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807114-A1 | BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1997-11-19 | — | — | EP | claimed |
| WO-1996023791-A1 | BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-08-08 | — | — | WO | claimed |