Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 6/20 | 0.47 |
| ▸ | RXRB | P28702 | 5/20 | 0.47 |
| ▸ | RXRG | P48443 | 3/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8408564 | 0.86 | MAPT (0.35) | KMT2AKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL8409037 | 0.84 | RXRA (0.53) | KMT2AKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL8798903 | 0.83 | RXRA (0.49) | KMT2AHPGDRXRARXRBRXRG | |
| SCHEMBL8797542 | 0.82 | RXRA (0.48) | KMT2AALDH1A1HPGDRXRARXRB | |
| SCHEMBL8406627 | 0.82 | KMT2A (0.62) | KMT2AKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL8406714 | 0.81 | RXRA (0.47) | KMT2AKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL8797990 | 0.81 | PTGER4 (0.54) | KMT2AKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL8796658 | 0.81 | RXRA (0.47) | KMT2AKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL8408062 | 0.80 | RXRA (0.45) | KMT2AKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL8406725 | 0.79 | RXRA (0.70) | KMT2AKDM4EMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778821-A1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LIMITED (GB) | 1997-06-18 | — | — | EP | disclosed |