Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799984 | 0.93 | PARP1 (0.40) | PARP1ALDH1A1SMN1; SMN2TP53CYP1A2 | |
| SCHEMBL8798897 | 0.86 | PARP1 (0.44) | PARP1CXCR3 | |
| Hydrochloric Acid SCHEMBL8799095 | 0.85 | PARP1 (0.43) | PARP1CXCR3 | |
| Cadaverine Tartrate SCHEMBL8800774 | 0.81 | PARP1 (0.41) | PARP1ALDH1A1MAPTCYP2C19 | |
| Cadaverine Tartrate SCHEMBL8801759 | 0.81 | PARP1 (0.41) | PARP1ALDH1A1MAPTCYP2C19 | |
| SCHEMBL8798739 | 0.81 | PARP1 (0.41) | PARP1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8798434 | 0.77 | PARP1 (0.48) | PARP1MAPT | |
| SCHEMBL8800588 | 0.76 | PARP1 (0.45) | PARP1SLC6A2 | |
| Hydrochloric Acid SCHEMBL8801079 | 0.76 | PARP1 (0.47) | PARP1MAPT | |
| Hydrochloric Acid SCHEMBL9484143 | 0.76 | PARP1 (0.47) | PARP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525584-B1 | 6-Oxo-azepinoindole derivatives, process and intermediates for their preparation and medicaments containing them | SOLVAY PHARM GMBH (DE) | 1997-12-10 | — | — | EP | disclosed |
| US-5272143-A | 6-oxoazepinoindole compounds, and pharmaceutical compositions containing them | KALI-CHEMIE PHARMA GMBH (DE) | 1993-12-21 | — | — | US | disclosed |
| EP-0525584-A1 | 6-Oxo-azepinoindole derivatives, process and intermediates for their preparation and medicaments containing them | Kali-Chemie Pharma GmbH (DE) | 1993-02-03 | — | — | EP | disclosed |