Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798987 | 0.82 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL8799404 | 0.81 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL8798834 | 0.80 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL8797851 | 0.75 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL8801127 | 0.75 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL3777336 | 0.68 | SMN1; SMN2 (0.62) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL236171 | 0.66 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| Hydrochloric Acid SCHEMBL9425361 | 0.65 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| SCHEMBL8799001 | 0.65 | LMNA (0.48) | PDE4APDE4BPDE4CPDE4DCHRM3 | |
| Hydrochloric Acid SCHEMBL9425417 | 0.64 | NPSR1 (0.47) | PDE4APDE4BPDE4CPDE4DCHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527117-B1 | Substituted cyclopropylamino-1,3,5-triazines | UCB SA (BE) | 1997-10-29 | — | — | EP | disclosed |
| US-5348956-A | Antiinflammatory and antiasthmatic agents | UCB S.A. (BE) | 1994-09-20 | — | — | US | disclosed |
| US-5258513-A | FOR TREATMENT OF ALZHEIMER'S DISEASE, SENILE DEMENTIA, EVOLUTIVE COGNITIVE PATHOLOGIES, DEPRESSION, ANXIETY, MOOD DISTURBANCES, INFLAMMATION AND ASTHMA | UCB S.A. (BE) | 1993-11-02 | — | — | US | disclosed |
| EP-0527117-A1 | Substituted cyclopropylamino-1,3,5-triazines | U C B, S.A. (BE) | 1993-02-10 | — | — | EP | disclosed |