Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594852 | 0.90 | PTGS2 (0.80) | PTGS2PTGS1 | |
| SCHEMBL5594991 | 0.90 | PTGS2 (0.80) | PTGS2PTGS1 | |
| SCHEMBL5594423 | 0.89 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL5594273 | 0.89 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL5594627 | 0.89 | PTGS2 (0.82) | PTGS2PTGS1 | |
| SCHEMBL5593864 | 0.89 | PTGS2 (0.82) | PTGS2PTGS1 | |
| SCHEMBL5594123 | 0.88 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL5594385 | 0.88 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL8798364 | 0.85 | PTGS2 (0.57) | PTGS2PTGS1GABRA2GABRB2 | |
| SCHEMBL8798034 | 0.83 | PTGS2 (0.78) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772600-A1 | 1,2-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003388-A1 | 1,2-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |