Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798204 | 0.81 | AKR1C3 (0.45) | GABRA1GABRG2GABRB3MAPTKDM4E | |
| SCHEMBL27593301 | 0.81 | NR1H2 (0.50) | NR1H2GABRA1GABRG2GABRB3MAPT | |
| SCHEMBL218643 | 0.78 | NR1H2 (0.48) | NR1H2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL1950813 | 0.77 | HRH3 (0.48) | NR1H2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL30534578 | 0.77 | HRH3 (0.48) | NR1H2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL8608562 | 0.76 | NR1H2 (0.46) | NR1H2GABRA1GABRG2GABRB3MAPT | |
| SCHEMBL8798790 | 0.74 | MAPT (0.46) | NR1H2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL24616867 | 0.71 | HSD17B3 (0.42) | NR1H2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL2570232 | 0.71 | HRH3 (0.49) | NR1H2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL397687 | 0.69 | NR1H2 (0.66) | NR1H2MAPTHSD17B3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790247-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE AND MEDICINAL PREPARATION CONTAINING THE SAME | TERUMO KABUSHIKI KAISHA (JP) | 1997-08-20 | — | — | EP | disclosed |